IONS insider transaction filings

IONIS PHARMACEUTICALS INC — 50 most recent Form 4 filings from SEC EDGAR, normalized by FilingPulse. Latest filing: 2026-09-02. Screen IONS transaction legs live →

Insider transaction summary — last 90 days

2026-06-24 to 2026-09-22, from the filings listed below: 24 Form 4 filings. Counts and totals are arithmetic on values as filed — descriptive data, not a recommendation.

By insider — same window

Open-market purchase/sale legs on non-derivative securities, grouped by the filing's reporting owner(s); joint filings appear once. Dollar totals cover priced legs only (shares × price as filed). Ordered by priced transaction value, largest first.

InsiderFilingsPurchases (P)Sales (S)Other legs
Monia Brett P — Chief Executive Officer, Director23 legs · 85,637 sh · $6,825,5247
Schneider Eugene — EVP, Chf Clinical Develop Ofcr11 leg · 26,000 sh · $2,107,1962
BENNETT C FRANK — EVP, Chief Scientific Officer22 legs · 20,536 sh · $1,744,6233
Hayden Michael R — Director22 legs · 20,000 sh · $1,058,7002
KLEIN JOSEPH III — Director12 legs · 11,518 sh · $910,4164
Diaz Allene M. — Director21 leg · 10,111 sh · $863,6374
Swayze Eric — EVP Research11 leg · 10,602 sh · $839,492
Baroldi Joseph — EVP, Chief Business Officer11 leg · 5,635 sh · $451,6994
O'NEIL PATRICK R. — EVP CLO & General Counsel21 leg · 3,069 sh · $245,5201
Kordasiewicz Holly B. — EVP, Chief Development Officer11 leg · 362 sh · $30,517

+7 more insiders in the window, not shown — every filing appears in the table below.

Recent Form 4 filings — IONIS PHARMACEUTICALS INC

FiledFormInsiderReported transactionsSource
2026-09-024BENNETT C FRANK — EVP, Chief Scientific OfficerOther (J): 110 @ $51.31EDGAR
2026-09-024Monia Brett P — Chief Executive Officer, DirectorOther (J): 98 @ $51.31EDGAR
2026-09-024O'NEIL PATRICK R. — EVP CLO & General CounselOther (J): 63 @ $51.31EDGAR
2026-09-024Birchler Brian — EVP, Corp and Development OpsOther (J): 58 @ $51.31EDGAR
2026-07-314Hayden Michael R — DirectorPurchase (P): 15,000 @ $53.38 · Purchase (P): 5,000 @ $51.60EDGAR
2026-07-174Reikes Peter N — DirectorGrant/award (A): 3,399 (derivative) @ $0EDGAR
2026-07-174HANTSON LUDWIG — DirectorGrant/award (A): 3,399 (derivative) @ $0EDGAR
2026-07-174HERMAN JOAN E — DirectorOption exercise (M): 5,220 @ $0 · Option exercise (M): 5,220 (derivative) @ $0EDGAR
2026-07-174BERTHELSEN SPENCER R — DirectorOption exercise (M): 5,220 @ $0 · Option exercise (M): 5,220 (derivative) @ $0EDGAR
2026-07-094Kordasiewicz Holly B. — EVP, Chief Development OfficerSale (S): 362 @ $84.30EDGAR
2026-07-094Diaz Allene M. — DirectorOption exercise (M): 10,111 @ $47.11 · Sale (S): 10,111 @ $85.42 · Option exercise (M): 10,111 (derivative) @ $0EDGAR
2026-07-094BENNETT C FRANK — EVP, Chief Scientific OfficerSale (S): 5,536 @ $83.58 · Other (J): 15,000 @ $0 · Sale (S): 15,000 @ $85.46 · Other (J): 15,000 (derivative) @ $0EDGAR
2026-07-064Diaz Allene M. — DirectorGrant/award (A): 5,369 (derivative) @ $0 · Grant/award (A): 2,301 (derivative) @ $0EDGAR
2026-07-064YANG MICHAEL J. — DirectorGrant/award (A): 5,369 (derivative) @ $0 · Grant/award (A): 2,301 (derivative) @ $0EDGAR
2026-07-064Hayden Michael R — DirectorGrant/award (A): 5,369 (derivative) @ $0 · Grant/award (A): 2,301 (derivative) @ $0EDGAR
2026-07-064LOSCALZO JOSEPH — DirectorGrant/award (A): 5,369 (derivative) @ $0 · Grant/award (A): 2,301 (derivative) @ $0EDGAR
2026-07-064HERMAN JOAN E — DirectorGrant/award (A): 5,369 (derivative) @ $0 · Grant/award (A): 2,301 (derivative) @ $0EDGAR
2026-07-064KLEIN JOSEPH III — DirectorOption exercise (M): 11,518 @ $39.94 · Sale (S): 99 @ $79.45 · Sale (S): 11,419 @ $79.04 · Option exercise (M): 11,518 (derivative) @ $0 · Grant/award (A): 5,369 (derivative) @ $0 · Grant/award (A): 2,301 (derivative) @ $0EDGAR
2026-07-064BERTHELSEN SPENCER R — DirectorGrant/award (A): 5,369 (derivative) @ $0 · Grant/award (A): 2,301 (derivative) @ $0EDGAR
2026-06-304Schneider Eugene — EVP, Chf Clinical Develop OfcrOption exercise (M): 26,000 @ $60.89 · Sale (S): 26,000 @ $81.05 · Option exercise (M): 26,000 (derivative) @ $0EDGAR
2026-06-304Baroldi Joseph — EVP, Chief Business OfficerOption exercise (M): 3,866 @ $56.78 · Option exercise (M): 1,769 @ $32.60 · Sale (S): 5,635 @ $80.16 · Option exercise (M): 1,769 (derivative) @ $0 · Option exercise (M): 3,866 (derivative) @ $0EDGAR
2026-06-304O'NEIL PATRICK R. — EVP CLO & General CounselSale (S): 3,069 @ $80EDGAR
2026-06-264Swayze Eric — EVP ResearchSale (S): 10,602 @ $79.18EDGAR
2026-06-264Monia Brett P — Chief Executive Officer, DirectorOption exercise (M): 14,565 @ $32.60 · Sale (S): 14,565 @ $78.41 · Option exercise (M): 21,072 @ $32.60 · Sale (S): 21,072 @ $78.49 · Option exercise (M): 50,000 @ $56.78 · Sale (S): 50,000 @ $80.59 · +3 moreEDGAR
2026-06-164Kordasiewicz Holly B. — EVP, Chief Development OfficerOption exercise (M): 7,951 @ $60.89 · Option exercise (M): 21,000 @ $60.89 · Option exercise (M): 12,000 @ $32.60 · Option exercise (M): 19,895 @ $56.78 · Sale (S): 41,004 @ $73.09 · Sale (S): 19,842 @ $74.05 · +4 moreEDGAR
2026-06-164BERTHELSEN SPENCER R — DirectorOption exercise (M): 8,000 @ $24.42 · Sale (S): 8,000 @ $73.49 · Option exercise (M): 8,000 (derivative) @ $0EDGAR
2026-06-084Reikes Peter N — DirectorGrant/award (A): 10,753 (derivative) @ $0EDGAR
2026-06-084HANTSON LUDWIG — DirectorGrant/award (A): 10,753 (derivative) @ $0EDGAR
2026-06-034BERTHELSEN SPENCER R — DirectorOption exercise (M): 8,000 @ $24.42 · Sale (S): 8,000 @ $75.67 · Option exercise (M): 8,000 (derivative) @ $0EDGAR
2026-05-154Monia Brett P — Chief Executive Officer, DirectorOption exercise (M): 1,316 @ $32.60 · Sale (S): 1,316 @ $78.01 · Option exercise (M): 3,220 @ $32.60 · Sale (S): 3,220 @ $78.68 · Option exercise (M): 1,316 (derivative) @ $0 · Option exercise (M): 3,220 (derivative) @ $0EDGAR
2026-05-064LOSCALZO JOSEPH — DirectorOption exercise (M): 10,968 @ $38.06 · Option exercise (M): 12,000 @ $40.05 · Option exercise (M): 10,321 @ $41.08 · Option exercise (M): 16,000 @ $42.88 · Option exercise (M): 12,000 @ $60.20 · Option exercise (M): 16,000 @ $64.80 · +8 moreEDGAR
2026-05-054KLEIN JOSEPH III — DirectorOption exercise (M): 10,111 @ $47.11 · Sale (S): 8,680 @ $73.35 · Sale (S): 1,431 @ $74.45 · Option exercise (M): 10,111 (derivative) @ $0EDGAR
2026-04-304Baroldi Joseph — EVP, Chief Business OfficerSale (S): 1,626 @ $71.79EDGAR
2026-04-174Birchler Brian — EVP, Corp and Development OpsOption exercise (M): 1,875 @ $0 · Sale (S): 973 @ $75.04 · Option exercise (M): 1,875 (derivative) @ $0EDGAR
2026-04-174Baroldi Joseph — EVP, Chief Business OfficerOption exercise (M): 10,837 @ $0 · Sale (S): 5,619 @ $74.56 · Option exercise (M): 10,837 (derivative) @ $0EDGAR
2026-04-174Jenne Kyle — EVP, Chf GL Pdt Str OfcrOption exercise (M): 12,226 @ $0 · Sale (S): 4,902 @ $75.17 · Option exercise (M): 12,226 (derivative) @ $0EDGAR
2026-04-174PARSHALL B LYNNE — DirectorSale (S): 4,466 @ $76.19 · Sale (S): 534 @ $76.97EDGAR
2026-04-024Devers Shannon L. — EVP, Chief Human Resources OfcSale (S): 6,193 @ $74.05EDGAR
2026-04-024KLEIN JOSEPH III — DirectorOption exercise (M): 12,000 @ $38.06 · Option exercise (M): 10,321 @ $41.08 · Sale (S): 20,105 @ $75.50 · Sale (S): 2,216 @ $75.95 · Option exercise (M): 12,000 (derivative) @ $0 · Option exercise (M): 10,321 (derivative) @ $0EDGAR
2026-03-234Schneider Eugene — EVP, Chf Clinical Develop OfcrSale (S): 5,812 @ $70.97EDGAR
2026-03-184HOUGEN ELIZABETH L — EVP, Finance & CFOOption exercise (M): 60,299 @ $60.89 · Option exercise (M): 61,041 @ $56.78 · Option exercise (M): 33,118 @ $32.60 · Option exercise (M): 20,541 @ $37.58 · Sale (S): 205,608 @ $72.38 · Sale (S): 9,440 @ $72.77 · +5 moreEDGAR
2026-03-114Jenne Kyle — EVP, Chf GL Pdt Str OfcrOption exercise (M): 32,602 @ $46.10 · Sale (S): 21,191 @ $75.50 · Sale (S): 16,086 @ $76.30 · Option exercise (M): 4,675 @ $34.69 · Option exercise (M): 4,675 (derivative) @ $0 · Option exercise (M): 32,602 (derivative) @ $0EDGAR
2026-03-114O'NEIL PATRICK R. — EVP CLO & General CounselSale (S): 10,148 @ $75.25EDGAR
2026-03-114Monia Brett P — Chief Executive Officer, DirectorOption exercise (M): 40,822 @ $60.89 · Option exercise (M): 73,529 @ $60.89 · Sale (S): 7,382 @ $74.11 · Sale (S): 117,604 @ $75.26 · Sale (S): 1,684 @ $75.58 · Option exercise (M): 34,103 @ $60.89 · +5 moreEDGAR
2026-03-054Devers Shannon L. — EVP, Chief Human Resources OfcOption exercise (M): 3,510 @ $37.58 · Option exercise (M): 3,760 @ $40.85 · Option exercise (M): 5,500 @ $34.69 · Option exercise (M): 6,951 @ $32.60 · Option exercise (M): 385 @ $52.87 · Sale (S): 14,321 @ $79.11 · +7 moreEDGAR
2026-03-054Baroldi Joseph — EVP, Chief Business OfficerSale (S): 4,096 @ $79.36 · Option exercise (M): 820 @ $56.78 · Option exercise (M): 879 @ $32.60 · Sale (S): 2,088 @ $80.41 · Sale (S): 36 @ $81.01 · Option exercise (M): 238 @ $56.78 · +7 moreEDGAR
2026-03-054Diaz Allene M. — DirectorOption exercise (M): 10,321 @ $41.08 · Option exercise (M): 12,000 @ $38.06 · Option exercise (M): 18,000 @ $40.05 · Sale (S): 39,265 @ $79.11 · Sale (S): 14,608 @ $79.88 · Sale (S): 1,005 @ $80.80 · +3 moreEDGAR
2026-03-054LOSCALZO JOSEPH — DirectorOption exercise (M): 832 @ $38.06 · Sale (S): 832 @ $80.33 · Option exercise (M): 200 @ $38.06 · Sale (S): 200 @ $80 · Option exercise (M): 832 (derivative) @ $0 · Option exercise (M): 200 (derivative) @ $0EDGAR
2026-03-054KLEIN JOSEPH III — DirectorOption exercise (M): 12,000 @ $40.05 · Option exercise (M): 4,000 @ $42.88 · Sale (S): 13,526 @ $79.17 · Sale (S): 6,794 @ $80.00 · Sale (S): 1,012 @ $80.82 · Option exercise (M): 12,000 (derivative) @ $0 · +1 moreEDGAR
2026-03-054BENNETT C FRANK — EVP, Chief Scientific OfficerOption exercise (M): 16,463 @ $32.60 · Option exercise (M): 48,626 @ $60.89 · Sale (S): 71,600 @ $79.10 · Sale (S): 12,687 @ $79.88 · Sale (S): 802 @ $80.76 · Option exercise (M): 16,463 (derivative) @ $0 · +1 moreEDGAR

Recent 8-K events — IONIS PHARMACEUTICALS INC

FiledFormItems reportedSource
2026-09-048-K7.01 — Regulation FD Disclosure
8.01 — Other Events
9.01 — Financial Statements and Exhibits
EDGAR
2026-09-048-K7.01 — Regulation FD Disclosure
8.01 — Other Events
9.01 — Financial Statements and Exhibits
EDGAR
2026-07-298-K2.02 — Results of Operations and Financial Condition
9.01 — Financial Statements and Exhibits
EDGAR
2026-07-108-K7.01 — Regulation FD Disclosure
9.01 — Financial Statements and Exhibits
EDGAR
2026-07-098-K7.01 — Regulation FD Disclosure
8.01 — Other Events
9.01 — Financial Statements and Exhibits
EDGAR
2026-06-248-K7.01 — Regulation FD Disclosure
8.01 — Other Events
9.01 — Financial Statements and Exhibits
EDGAR
2026-06-128-K8.01 — Other Events
9.01 — Financial Statements and Exhibits
EDGAR
2026-06-088-K5.02 — Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers
5.07 — Submission of Matters to a Vote of Security Holders
7.01 — Regulation FD Disclosure
9.01 — Financial Statements and Exhibits
EDGAR
2026-05-288-K7.01 — Regulation FD Disclosure
8.01 — Other Events
9.01 — Financial Statements and Exhibits
EDGAR
2026-04-298-K2.02 — Results of Operations and Financial Condition
9.01 — Financial Statements and Exhibits
EDGAR
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